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Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohns disease features skip lesions areas of diseased bowel separated by segments of normal-appearing tissue and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohns & Colitis Foundation

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However, when patients stopped taking Tesamorelin, the fat reduction benefits were quickly reversed, suggesting that continued use is necessary to maintain results