PMID: 7 FerrazEBorgesMCTerra-FilhoJMartinezJAViannaEO
Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90
This involves histamine release due to a direct action of the medication (not an IgE-mediated allergic reaction)
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Holton [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
