[DOI] [PMC free article] [PubMed] [Google Scholar] Sanderson P
In terms of iron metabolism, studies have found increased iron content in IBD intestinal tissues, higher levels of Fe2+ involved in the Fenton reaction of cellular ferroptosis, and significantly elevated mRNA and protein levels of FTL and FTH1
The following section introduces the key aspects of ferroptotic cell death
Theodoropoulos, J
Kulik, U., Moesta, C., Spanel, R
The NMNAT1 and NMNAT3 transgenic mouse strains used here were as previously described (Yahata et al, 2009), and the colony was maintained through breeding heterozygous males with wild-type females, with a subsequent Mendelian ratio of offspring to be used for experiments of 50% heterozygous transgenics, and 50% wild-type littermate controls