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The consequences of thiamine deficiency such as increased oxidative stress, excitotoxicity, and inflammation, lead to cerebral vulnerability

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A separate meta-analysis that pooled results of trials in older adults with mild cognitive impairment found B-vitamin supplementation (6 to 24 months, depending on the trial) had no benefits on various cognitive parameters, including executive function, information processing speed, and episodic memory (90)

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The acetate form includes an acetate salt, which may affect formulation and stability considerations

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