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Combining pulldown experiments and functional assays to identify senolytic targets To identify the targets responsible for their senolytic activity, we synthesized two alkynylated derivatives of each compound, which we used to perform target identification in competitive, protein-directed activity-based protein profiling (ABPP) experiments (Fig

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Also, the antitumor immune responses elicited by MnLR/Gly are not confined to a single immune cell type and might even involve the participation of immune cells beyond T cells or macrophages

& Mumbrekar, K

BBB dysfunction is increasingly recognized in the context of aging and can contribute to the onset of cognitive disorders