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Objective biomarkers like rising malondialdehyde and inflammatory cytokines (IL-6, TNF-alpha) become measurable around 1014 days post-discontinuation

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When miR-146a levels rise, two key TLR signaling proteins, IRAK1 and TRAF6, may decrease, and thus they may not transmit inflammatory signals inside the cell, including pathways linked to NF-B activation, which would otherwise play a major role in inflammatory signaling