Downregulation of CH25H alters endosomal dynamics by promoting membrane fusion between endophagosomes and lysosomes
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Insufficient intake of magnesium, loss of magnesium through the digestive system and kidneys, and redistribution of magnesium from the extracellular space to the intracellular space are the main causes of magnesium deficiency (182)
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These cargos typically fall into two categories: proangiogenic agents (e.g., VEGF mRNA [66]) to restore placental vascular function, or inhibitors of pathogenic factors to block PE-driven signaling cascades [67]