Sweeney MD, Sagare AP, Zlokovic BV (2018a) Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
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In an early trial, a population with equally distributed pre-menopausal and post-menopausal status only including pre-treatment cases (chemotherapy with or without radiotherapy and/or hormonotherapy) with metastatic disease (skin 36%, lymph nodes 34%, bone 42%, and visceral 97%) underwent PTX 135 mg/m 2 versus 175 mg/m 2 infusion over 3 h every 3 weeks
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Chronic inflammation, heavy metal exposure, hormone imbalance, adrenal dysregulation, and intestinal permeability can all contribute to symptom severity
However, challenges remain, including standardization, herb-drug interaction studies, large-scale clinical trials, and regulatory harmonization