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They also restore total superoxide dismutase (T-SOD) activity to reduce oxidative stress and modulate apoptotic signaling via downregulation of the Bax/Bcl-2 ratio, contributing to alveolar epithelial cell protection

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532 Another candidate, ultevursen (QR-421a), is an ASO therapy for treating vision loss in patients with pigmentary retinopathy due to mutations in exon 13 of the USH2A gene

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