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In cell cultures and mouse models of HD as well as in patient samples, the levels of CSE are drastically diminished, due to the sequestration of SP1 by mHtt (Paul et al ., 2014)

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Similar in vitro work showed that HGF promoted dendritic arborization in hippocampal neurons, an effect that could be blocked by NMDA receptor antagonists and was dependent on intracellular calcium and CaMKII activity [2]

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