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doi: 10.1016/S0022-3999(01)00315-4 Summary Keywords Sensewear armband, myalgic encephalomyelitis/chronic fatigue syndrome, vitamin B12 nasal drops, vitamin B12 serum concentration, RAND 36 questionnaire Citation van Campen CLMC, Riepma K and Visser FC (2019) Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders
El rango ptimo generalmente aceptado es 0.1-0.3% (1,000-3,000 ppm) aplicado 1-2 veces/da sobre piel limpia
Serious systemic reactions: rare but possible Reports exist of anaphylaxis and severe allergic responses after vitamin B12 injections
No evidence of tolerance development (requiring progressively higher doses to achieve the same effect) or physical dependence (withdrawal symptoms upon discontinuation) has been documented in available research, distinguishing DSIP favorably from traditional sleep medications that commonly cause both tolerance and dependence
The winner will depend on Phase 3 data, tolerability, approval timing, label breadth, payer access, and real-world persistence
