FDX1, a target of the copper ionophore elesclomol, reduces Cu 2 to its more toxic form, Cu, and regulates protein lipoylation through interaction with lipoic acid synthetase (LIAS), which catalyzes the final step of lipoic acid biosynthesis (Figure 2) (Tsvetkov et al., 2022
Weber AE, Gallo MC, Bolia IK, Cleary EJ, Schroeder TE, Hatch GFR
(2018) Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis
The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
Zhao et al., 2019)
Atpenin A5, blocking succinate dehydrogenase, inhibited SARS-CoV-2, dengue virus, respiratory syncytial virus, and influenza A virus with high selectivity indices