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The aesthetic and social embarrassment felt by these subjects represents an important issue to address, affecting the peoples quality of life
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Neurocognitive functions like memory, orientation, computation, and abstract thinking were also enhanced
On the other hand, berberine can inhibit ERK phosphorylation (Lu et al., 2010), and induce the phosphorylation of Liver kinase B1 (LKB1) (Ser428), calcium/calmodulin-dependent protein kinase II (CaMKII) (Thr286), and AMPK (Thr172) (Lu et al., 2010)