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When fish perceive a stressor, the hypothalamus secretes corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH)

The complex appears in research on oxidative stress, on the regulation of antioxidant gene networks, and on copper homeostasis more generally

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doi: 10.1109/JPHOT.2020.2973653 36 BiziukM.StockaJ

5 6 7 8 Recent narrative and scoping reviews specifically note the near-absence of human efficacy data and, for BPC-157, a reliance on a limited number of research groups