Angiogenesis 22 , 341354 (2019)
N-to-B delivery is a non-invasive method that enables drug delivery to the CNS, bypassing the BBB through the only place that directly connects the CNS with the environment [9,15,16]
If this difference was due to a matrix effect, we would expect to observe different levels of total GSH between the two anticoagulants
This axis is closely associated with the occurrence and development of AD: there is a significant increase in oxidative stress and a decrease in GSH levels in the AD brain, leading to impaired GPX4 activity, massive accumulation of lipid peroxidation products in neuronal cell membranes, and accelerated neuronal ferroptosis
It can not only directly participate in redox reactions, but also act as a substrate or cofactor for numerous detoxifying enzymes (Meister and Anderson, 1983)
In : Methods of Enzymatic Analysis (Bergmeyer HU, ed.), 3rd ed., Vol