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Treatment with resveratrol during in vitro maturation (IVM) has been shown to reverse the adverse effects of oxidative stress on oocytes, improve blastocyst production from oocytes, increase mtDNA copy numbers, and elevate ATP content in oocytes and subsequent embryo development ability as well as raise the rates of fertilization in postovulatory aging (POA) oocytes, maintain the normal morphology of spindle and mitochondrion distribution, and alleviate early apoptosis (Itami et al., 2015

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15 Pharmacologic Considerations of the Subcutaneous Route (PMC)Subcutaneous injection technique and site rotation to prevent lipohypertrophy