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Oxidative Imbalance and Reduced GR Function Several specific scenarios create conditions where hydrogen water's mechanism may provide advantages over relying solely on GR-mediated glutathione recycling: NADPH deficiency states : Conditions that compromise NADPH production, such as glucose-6-phosphate dehydrogenase deficiency, metformin therapy, or severe caloric restriction, limit GR function due to insufficient cofactor availability

Therefore, elucidating the association between oncogene expression and metabolic characteristics could enable more precise metabolic interventions in clinical settings

29 , 10031011.e4 (2019)