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We therefore purified R615C pig RyR1 (pRyR1) directly from homozygous pig tissue, as we described before 38

While a moderate increase in ROS is tolerated and may even be advantageous for survival 6 , excessive ROS accumulation leads to cell death 7

NO also plays a role in the redox state within the skeletal muscle, partially through its interaction with respiratory chain enzymes and transcriptional regulators of antioxidant production

Three reviewers (JY-L, QQ-X, and SJ-X) selected and reviewed the literature

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