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Polyphenols are also subject to various denaturing conditions (103), such as heat, light, oxygen, pH variations, and enzymatic degradation, which reduce their bioavailability and limit their efficacy as bioactive compounds (108)

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Some of these include the stomach, inner thighs, neck, buttocks and hips

This particular early noxious effect of isoprenaline has not been investigated so far, but it can be likely antagonized by BPC 157 therapy application