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Most researchers report initial subtle improvements within 7 to 10 days, with significant changes in sleep quality emerging over 3 to 6 weeks

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This relatively small size researchers note allows for efficient study of its cellular signaling behavior compared to larger peptide compounds

Also, we did not include the studies on melatonergic agonists, such as ramelteon, tasimelteon, and agomelatine, but focused on the efficacy and safety of exogenous melatonin supplementation

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