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Theoretical concerns about chronic NNMT inhibition include effects on the metabolism of other quinolinium and methylpyridinium endogenous metabolites and on the broader cellular methylation landscape

Patients experiencing nausea, early satiety, or food aversions may inadvertently reduce their consumption of these B12-rich foods, potentially leading to deficiency over time

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This usually occurs in individuals with underlying digestive conditions, those who have trouble absorbing all nutrients through digestion, or those with pernicious anemia, which specifically prevents B12 absorption

Lab tests show the compound can enhance mitochondrial function through pathways similar to exercise, making it useful for researchers studying cellular adaptation mechanisms

Although your body is unable to generate B-12, the vitamin is readily available from dietary sources including dairy, meat and fish