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Dosing & Reconstitution Guide Educational guide for reconstitution and nightly dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Inject once daily subcutaneously at bedtime

It provides immediate visual confirmation that the vial contains B12

This observation substantiated the glutamate hypothesis and glutaminergic dysfunction as a mechanism underlying both positive and negative symptoms, as well as cognitive dysfunction, in schizophrenia [194]