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While individual sensitivity varies, caffeine has a half-life of approximately 5 to 6 hours, meaning half of the caffeine from an afternoon coffee remains in your system at bedtime

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Building long-term, sustainable habits you can maintain is better for your health in the long run than quick fixes

Future studies should investigate whether p53 ablation in adipocytes, with concomitant reduction in the abundance of AT macrophages, might lead to differences in weight (re-)gain after return to normal or obesogenic diet, to further test the hypothesis that adipocyte p53 is key in establishing an immuno-obesogenic memory of AT that promotes weight regain