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Although many monoaminergic treatments exist, at least a third of patients do not have a response after two or more trials of antidepressant drugs and are considered to have treatment-resistant depression ( Ketamine is a mixture of two enantiomers (mirror image molecules): R- and S-ketamine

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Benassi, B., et al., c-Myc phosphorylation is required for cellular response to oxidative stress

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