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Naturally occurring bioactives have emerged as promising adjunct or alternative therapeutic agents in this context

In female nude mice inoculated subcutaneously with MCF-7/6 human breast adenocarcinoma cells, the combination of tangeretin and TAM counteracted the tumor growth inhibition effect of TAM (Bracke et al., 1999)

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The risk of dosing errors, infection, and serious adverse reactions is substantial without professional oversight and clinical monitoring