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As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results

Unlike all previous menthol brands, which impregnated the aromatic compound directly into the tobacco, Salem instead provided its burst of minty freshness to unflavored tobacco by way of a mentholated filter

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