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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

through the processes of cytochrome C release, cysteine protease activation, and membrane potential of mitochondria loss induces cell death

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In its function as a cellular caretaker, attenuation of GSTP1 expression or activity by either genetic (e.g., deletion or mutation) or epigenetic alterations may reduce cellular detoxification capacity ( Figure 2 )

These results further suggest that hepsin / mice experienced increased oxidative stress in the early hours following APAP administration, leading to more severe drug-induced liver damage (Fig

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