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Alzheimer Dis Assoc Disord 30(3):251257

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Furthermore, loss of DJ-1 in astrocytes leads to hyperactivation of inflammatory responses upon LPS stimulation, resulting in excessive production of nitric oxide (NO), COX-2, and IL-6 via a ROS-p38 MAPK pathway (Waak et al., 2009)

3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

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