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Cell Reports (2019) 8

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It has been found that the expression level and function of Sirt3 is selectively reduced in the spinal cord of SOD1G93A mice at the end of ALS course, while the level of Sirt3 is increased in the human spinal cord after autopsy

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By avoiding GH receptor activation, AOD-9604 may offer regenerative benefits with reduced systemic complications

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