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One of the mechanisms by which CerS2 ablation impairs GSIS is through reduction in the level of the protease, PCSK1, responsible for processing proinsulin to functional insulin

PMID: 40789979 Chang CH, Tsai WC, Lin MS, et al

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This is when progesterone rises, metabolism shifts, and the body may require more calories and rest (not less.) In women, stress and thyroid hormones are also important to consider because imbalances can increase the impact of both fasting and GLP-1 medications

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