Senolytics focus on eliminating senescent cells, while senomorphics prevent the harmful extrinsic effects of senescent cells by selectively targeting and inhibiting the development of the SASP [98]
Collaborative efforts among researchers, clinicians, and policymakers are essential to translate these innovations into clinical practice, ensuring equitable access to advanced therapies worldwide
Increased number of oocytes retrieved in the treated group (12 versus 8.5) Higher % of mature oocyte in the treated group (82% versus 63%) % of immature oocyte (degenerated or vesicle germinal) was significantly reduced in the treated group (2.3% versus 24%) Higher % of score 1 embryos (good quality embryo) in the treated group (70% vs
Cardenas, P
Personalized Care : In order to meet the needs of each patient, each treatment is customized to meet those needs
==== 00:00 Intro 03:12 Epigenetics and Neurodegenerative Disease 04:49 Why Alzheimers Is Not a Single Gene Disorder 09:18 Protein Aggregation and Brain Cleanup Failure 10:55 Microglia vs Neurons in Alzheimers 19:04 Blood Brain Barrier and Inflammatory Signaling 20:39 ApoE Genetics Explained 23:37 Human Microglia Transplanted Into Mouse Brain 30:02 Vitamin D Receptor and Protective Gene Programs 38:18 Environmental Toxins and Parkinsons 44:59 C1q Activation and Synapse Loss 49:33 Why Substantia Nigra Is Uniquely Vulnerable 51:39 Paraquat, Mitochondria and Converging Toxic Pathways 53:00 Epigenetic Memory of Toxic Exposure 54:09 Histones and Gene Regulation in Alzheimers 57:41 Oligodendrocytes as a Hidden Player 59:32 Why Single Target Drugs May Fail 01:02:10 Detecting Disease Through Blood and Machine Learning 01:04:41 Can Lifestyle Modify Epigenetics ==== Dr Sarah Marzi is a Senior Lecturer in Neuroscience at Kings College London and a Group Leader at the UK Dementia Research Institute
