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However, under pathological conditions such as tumor development, bone marrow transplantation, severe trauma, infection, inflammatory immune responses, and various AIDs, the expression of immunosuppressive factors is significantly upregulated, inhibiting the normal differentiation of myeloid progenitor cells and leading to abnormal expansion and accumulation of MDSCs
Jan 1995;47(1):312-318
Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD
Volchegorskii I
Together, these metabolic alterations suggest a biochemical framework in which inflammation, oxidative stress, and TTR misfolding may be interconnected in TTR-V30M amyloidosis