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(2013) characterized the role of NNMT in cancer cell metabolism, demonstrating that NNMT activity creates a metabolic sink for SAM

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Against retinoids: GHK-Cu in the Abdulghani trial outperformed tretinoin without the irritation, peeling, and sun sensitivity that retinoids commonly cause

Ignores cellular levels: The total-B12 blood test fails to record whats happening at the cellular level

This is the run-in period where NNMT inhibition is being established

Through a spokesperson, Vinjamoori declined to identify a specific standard of care