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Additionally, it influences the immune, cardiovascular, reproductive and gastrointestinal systems

Sustained depletion of NRF2 upon Gclc deletion induces a sex-dependent requirement for NRF2 to maintain liver homeostasis and animal survival Liver-specific deletion of Gclc impaired the expression of lipogenic enzymes and lowered circulating triglyceride levels

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INSR B -IGF1R hybrids comprises up to 30% of INSR and IGF-I receptors in muscle due to high expression of both and this hybrid predominantly responds to IGF-I (less to insulin) and explains the important role of IGF-I in growth and metabolism in skeletal muscle

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References Wang Y, Liu S, Hu Y, Li P, Wan J-B