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The fact that mutant ATXN3 aggregates are also found in axons and that components that ensure protein homeostasis are in close proximity led to the hypothesis that the aggregation process occurring within axons may affect mechanisms of axonal transport of mRNA, proteins, and organelles and thereby contribute to a wider neuronal dysfunction in SCA3 [30]

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Studies were restricted to those published in English

With that insight, researchers intend to develop scripts for physicians and nurse practitioners to use in educating and counseling patients nationwide