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ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)

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Resistance training stimulates anabolic pathways and increases IGF-1 activity

While it may not be a miracle solution, its role in promoting cellular resilience makes it worthy of consideration in any comprehensive approach to longevity

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This is why freckles tend to darken during the sunny months and lighten when sun exposure decreases