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If you have wide variations in the pH level of the water flowing through the old lead service lines, you can create a softer layer in that coating, like in the snowpack when theres a softer, weaker layer of snow, it can cause an avalanche, Poncelet-Johnson said

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So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

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Most therapeutic peptides are administered by injection