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doi: 10.1079/bjn20041221 162 QuandtGHfnerGWannerKT

Sirtuins, also known as NAD + -dependent class III HDACs, remove the acetyl groups from histone, which restores the electrostatic affinity between DNA and histones to stabilize the chromatin architecture

Stres oksidatif biasanya muncul karena adanya ketidakseimbangan antara radikal bebas yang masuk ke dalam tubuh, serta kemampuan tubuh untuk melawannya