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I., Sasaki, M., Beroukhim, R., Stephanopoulos, G., Ligon, A

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Moreover, a novel mouse model engineered to have enhanced cholesterol synthesis by SREBP-2 overexpression superimposed to APP/PS1 mutations triggered A accumulation and tau pathology ( in vivo replenishment of mGSH with cell- permeable GSH monoethyl ester (GSHEE) attenuated neuropathological features of AD in SREBP-2/APP/PS1 mice

Cureus 15, e38184

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Since these organelles are not capable of de novo biogenesis new ones are generated by expansion and fission of the existing mitochondria with the cell