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Although ischemia is the main culprit in strokerelated injuries, another crucial part of the stroke is reperfusion, an event taking place after the ischemic area is resupplied with blood (Chamorro, Dirnagl, Urra, & Planas, 2016

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It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)

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