Lithium intoxication and nephrogenic diabetes insipidus: a case report and review of literature
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When toxic exposure or chronic inflammation is too high, Phase 1 rapidly uses up the liver's glutathione reserves, causing Phase 2 to come to a screeching halt
Because of glutathiones role as an antioxidant, people without enough of it may have more cell damage from free radicals due to a disproportionate amount of oxidative stress
This event initiates the mitochondrial permeability transition, a critical step in the cell death process (Fig