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Nevertheless, while animals represent a tool to study NAFLD and NASH, it is unlikely that any single animal model will reflect all aspects of human NASH and researchers must critically select the model(s) best suited for the subject of investigation

For years, researchers avoided glucagon activation because glucagon raises blood sugar, which seemed counterproductive for a metabolic medication

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Tumor microenvironment has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis and the microenvironment supports metastatic dissemination and colonization at secondary sites

Similarly, cardiovascular disease is the leading cause of mortality in diabetic patients, highlighting the broad therapeutic value of this effect