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GSH depletion triggers the lymphocytes apoptotic cascade leading to lymphopenia that affects for the most part T lymphocytes, and lymphopenia is directly associated with severe disease and high mortality rate in COVID-19 patients (Pallard et al., 2009

Moreover, they found that overexpression of ferroportin (FPN) suppressed Erastin-induced ferroptosis in EESCs, whereas FPN deficiency accelerated this process (38)

Correlated with this decrease in GSH levels, we found that the T2DM group also has significantly higher levels of MDA ( Figures 3B, C ) and higher levels of the proinflammatory cytokine IL-6 ( Figure 3D ) than the healthy group

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