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Rotating injection sites consistently and allowing the solution to reach room temperature before injecting minimizes these reactions

Vitamin C: Interestingly, Vitamin C and glutathione work in a continuous loop

The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14

Figure 3 Additionally, the activation of NF-B leads to increased expression of key genes, including proinflammatory cytokines like IL-6, IL-8, IL-16, and TNF-, which contribute to inflammation

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& Richie, J