Arevalo GE, Frank MK, Decker KS, Theodoraki MA, Theodorakis EA (2023) Gambogic acid: multi-gram scale isolation, stereochemical erosion toward epi-gambogic acid and biological profile
These pH-sensitive cleavable linkers remain stable in plasma while rapidly cleaving in the acidic environment of tumor cells to release cytotoxic payloads
Calcium-independent phospholipase A2 (iPLA2)-mediated lipid peroxidation detoxification is sufficient to inhibit p53-driven ferroptosis under ROS-induced stress and acts as a major ferroptosis suppressor independent of GPX4, suggesting that iPLA2 is a promising therapeutic tumor target (68)
Kim E, Choi Y, Jang J, Park T
Do not use as a sole source of nutrition
Zofran can be added onto this infusion to combat any nausea if applicable