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"If someone experiences benefits or side effects, we don't know if they're from the peptide or because of impurities, endotoxins, or anything else that could be in there," Husain says

Research shows the nasal cavity maintains a pH range of 5.5 to 6.5, and formulations must match this range to avoid irritation and peptide degradation

J R Stat Soc Ser A Stat Soc 177

Retrieved 2 February 2015

The peptides most commonly discussed for ED work through several proposed mechanisms

B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease