In summary, despite high adherence to oral supplementation and a low frequency of side-effects, oral glutathione supplementation did not result in significant changes in biomarkers of lipid peroxidation, DNA adduct formation or glutathione status in healthy adults

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For years, the efficacy of oral glutathione was heavily debated, but a landmark 6-month randomized, double-blind, placebo-controlled clinical trial conducted at Penn State University definitively challenged the myth of poor absorption
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3,27 Biochemical features of the disease, such as insulin resistance, systemic inflammation, and high circulating male hormone levels, as well as PCOS manifestations (menstrual problems and infertility), may be contributing factors in the elevated risk of psychological complications
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