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These findings actively support the importance of GPX4 in preventing activated Treg cells from ferroptosis and lipid peroxidation and suggest a potential therapeutic avenue to optimize cancer therapy
To overcome these challenges, strategies 5 such as pH optimization, use of stabilizing excipients (buffers, antioxidants, surfactants), lyophilisation, and controlled storage conditions are employed
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Disclosures Disclosure forms, as provided by each author, are available with the online version of the article at Author Contributions Conceptualization: Yuki Sugiura, Motoko Yanagita
doi: 10.1002/jnr.23284
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