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In neurons, cyclin-dependent kinase 1 (CDK1) phosphorylates Drp1 at Ser616 activating mitochondrial fission

To ask whether the YBX1AMPK axis similarly exists in human macrophages, we treated human THP-1 monocyte cells with phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS), as described previously 44

10.1016/j.neuropharm.2007.08.017 Neuropharmacology 91 SalminenO.MurphyK.McIntoshJ.DragoJ.MarksM.CollinsA.et al (2004)

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10.1007/s10725-010-9519-0 53 LovellS

These studies highlight the potential anti-cancer properties of eptihalon in animal models and suggest that further research in this area remains warranted