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Two independent reviewers screened articles by title and abstract, followed by full-text assessment to exclude studies not primarily related to DPN, with disagreements resolved through consensus

Induction of intestinal Th17 cells by segmented filamentous bacteria

CAP, Cholinergic anti-inflammatory pathway

Cabaas, R

Reviews note that most observed benefits occur within commonly studied ranges, while gastrointestinal side effects such as bloating or loose stools become more common as intake increases.12 13 43 44 For that reason, most evidence-based supplement protocols fall within the 24g per day range , which reflects the doses most often studied in humans and balances potential benefit with tolerability.7 Are inositol supplements safe